Dr. Rachita Sumbria

Dr. Rachita Sumbria

副教授
药学院
办公地点: 林克健康科学校园94-297V
Phone: 714-516-5470
Education:
化工学院，工学学士
德克萨斯理工大学，博士.D.

Biography

Dr. Sumbria joined 澳门威尼斯人app下载大学 药学院 as an 副教授 in February of 2021. Dr. Sumbria received her PhD in Pharmaceutical Sciences from the Texas Tech University Health Sciences Center (TTUHSC) in 2010. At TTUHSC, her research centered on the development of intracerebral microdialysis as an experimental tool to study changes in the blood-brain barriers (BBB) permeability in ischemic stroke.

Dr. Sumbria completed her postdoctoral training at the Department of Medicine, 加州大学的血脑屏障实验室, Los Angeles and the Department of Neurology at the University of California, 从2011年到2014年. 在加州大学洛杉矶分校进行博士后研究期间. Sumbria专注于中枢神经系统药物输送中的血脑屏障瓶颈问题. Particularly, her research focused on the use of receptor-mediated transcytosis for non-invasive delivery of biologics and other large molecular weight therapeutics across the BBB, and studying their pharmacologic effects in different experimental models of CNS disorders. At UCI, the focus of her research was studying the role of cerebral microbleeds in cerebrovascular diseases like stroke. In 2014, she joined the faculty at the 药学院 and Health Sciences at the Keck Graduate Institute as an Assistant Professor and was promoted to 副教授 in 2019. 在她的学术生涯中. Sumbria has been extensively involved in research that has been funded by federal and foundation grants, teaching and mentoring laboratory research personnel and graduate students. 

最近的创意，学术工作和出版物

昌R，桑布里亚RK. 小鼠脑微出血的定量评价. 方法:. 2023;2616:181-190.PMID: 36715935.
Fang, C., Lau, W.L., Sun, J., Chang R., Vallejo A., Lee D., Liu J., Liu H., Hung YH., Zhao Y.帕格尼尼-希尔A., Sumbria RK., Cribbs DH., Fisher M. 慢性肾脏疾病促进脑微出血的形成. [J]中华神经科学杂志，2001,21(4):444 - 444。.
Yang, J.; Ou, W.; Jagadeesan, N.; Simanauskaite, J.; Sun, J.; Castellanos, D.; Cribbs, D.H.; Sumbria, R.K. The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy. 医药，2023,16,558.
Chandrashekar D.V.; Steinberg, R.A.; Han, D.; Sumbria, RK. Alcohol as a Modifiable Risk Factor for Alzheimer’s Disease — Evidence from Experimental Studies. Int. J. Mol. Sci. 2023, 24, 9492.
Imran Sajid M, Sultan Sheikh F, Anis F, Nasim N, Sumbria RK, Nauli SM, Kumar Tiwari R. siRNA drug delivery across the blood-brain barrier in Alzheimer's disease. Adv药物递送Rev. 2023年8月,199:114968. Epub 2023 6月21日. PMID: 37353152.
Zhang H$, Sumbria RK*$, Chang R$, Sun J, Cribbs DH, Holmes TC, Fisher MJ*, Xu X*. Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo. [J]中国生物医学工程学报，2016,33(4):444 - 444。. $ first authors *通讯作者
李建平，李建平，李建平，李建平*. Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections. J. Vis. Exp. (183)， e63669, doi:10.3791/63669 (2022).
Sun J, Ou W, Hill PA, Han D, Fisher MJ, Sumbria RK* Comparative studies between the murine immortalized brain endothelial cell line (bEnd.3) and induced pluripotent stem cell-derived human brain endothelial cells for paracellular transport. PLOS One. 2022年5月25日;17(5):e0268860. doi: 10.1371/journal.pone.0268860.
Feinberg PA, Becker SC, Chung L, Ferrari L, Stellwagen D, Anaclet C, Duran-Laforet V, Faust TE, Sumbria RK, Schafer DP*. Elevated TNF-a leads to neural circuit instability in the absence of Interferon Regulatory Factor 8. J Neurosci. 2022年7月1日:JN-RM-0601-22. doi: 10.1523/JNEUROSCI.0601-22.2022.
Garcia J, Chang R, Steinberg RA, Arce A, Yang J, Van Der Eb P, Abdullah T, Chandrashekar DV, Eck SM, Meza P, Liu ZX, Cadenas E, Cribbs DH, Kaplowitz N, Sumbria RK, Han D*. Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-ß. Front Physiol. 2022年9月15日;13:930402. doi: 10.3389/fphys.2022.930402. PMID: 36187787; PMCID: PMC9520570.
Ou W, Ohno Y, Yang J, Chandrashekar DV, Abdullah T, Sun J, Murphy R, Roules C, Jagadeesan N, Cribbs DH, Sumbria RK*. Efficacy and Safety of a Brain-Penetrant Biologic TNF-a Inhibitor in Aged APP/PS1 Mice. Pharmaceutics. 2022; 14(10):2200.
Sun J, Vyas P, Mann S帕格尼尼-希尔A, Nunes AC, Lau WL, Cribbs DH, Fisher MJ, Sumbria RK. 脑内皮细胞红细胞吞噬作用机制的研究. Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.672009.
Yang J, Sumbria RK* The concentration of brain homogenates with the Amicon Ultra Centrifugal filters. MethodsX. 2021;8:101584.
Ou W, Yang J, Simanauskaite JM, Choi M, Castellanos DM, Chang R, Sun J, Jagadeesan N, Parfitt KD, Cribbs DH, 生物TNF-a抑制剂减少小胶质细胞增生, neuronal loss, 以及tau蛋白磷酸化在tau病转基因小鼠模型中的作用. J神经炎症. 2021;18:312
Sumbria RK. Targeting the transferrin receptor to develop erythropoietin for Alzheimer’s disease. 神经再生. 2020;15(12):2251-2252.
杨军，孙军，Castellanos DM, Zambon AC, Pardridge WM, Sumbria RK. Eliminating Fc N-linked glycosylation and its impact on dosing consideration for a transferrin receptor antibody-erythropoietin fusion protein in mice. Mol Pharm. 2020年8月3日;17(8):2831-2839.
Castellanos, D.M.; Sun, J.; Yang, J.; Ou, W.; Zambon, A.C.; Pardridge, W.M.; Sumbria RK. Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice. 医药科学，2020,12,852.
孙杰，Martin JM, Vanderpoel V, Sumbria RK. The Promises and Challenges of Erythropoietin for Treatment of Alzheimer's Disease. Neuromol Med. 2019年3月,21 (1):12 - 24. PubMed PMID: 30656553; PubMed Central PMCID: PMC6407698.
孙杰，Boado RJ, Pardridge WM, Sumbria RK. Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice. Mol Pharm. 2019年8月5日;16(8):3534-3543. PubMed PMID: 31199881; PubMed Central PMCID: PMC6684820.
Michael N, Grigoryan MM, Kilday K, Sumbria RK, Vasilevko V, van Ryn J, Cribbs DH帕格尼尼-希尔A, Fisher MJ. Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy. Front Neurol. 2019;10:966. PubMed PMID: 31611836; PubMed Central PMCID: PMC6776875
Sun J, Yang J, Whitman K, Zhu C, Cribbs DH, Boado RJ, Pardridge WM, Sumbria RK. Hematologic safety of chronic brain-penetrating erythropoietin dosing in APP/PS1 mice. 老年痴呆症(N Y). 2019;5:627-636. PubMed PMID: 31660425; PubMed Central PMCID: PMC6807369.
Sumbria RK, Grigoryan MM, Vasilevko V帕格尼尼-希尔A, Kilday K, Kim R, Cribbs DH, Fisher MJ. 在小鼠模型中，衰老加剧了脑微出血的发展. J神经炎症. 2018年3月6日;15(1):69. PubMed PMID: 29510725; PubMed Central PMCID: PMC5840821.
张瑞平，刘建军，刘建军，刘建军，刘建军. Brain Endothelial Erythrophagocytosis and Hemoglobin Transmigration Across Brain Endothelium: Implications for Pathogenesis of Cerebral Microbleeds. 前细胞神经科学. 2018;12:279. PubMed PMID: 30237761; PubMed Central PMCID: PMC6135875.
Chang R, Al Maghribi A, Vanderpoel V, Vasilevko V, Cribbs DH, Boado R, Pardridge WM, Sumbria RK. Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease. Mol Pharm. 2018年11月5日;15(11):4963-4973. PubMed PMID: 30252487; PubMed Central PMCID: PMC6457666.
张瑞，余国良，张国良. 肿瘤坏死因子a抑制阿尔茨海默病. 神经系统疾病. 2017年5月15日;9:11 179573517709278. PubMed PMID: 28579870; PubMed Central PMCID: PMC5436834.
Sumbria RK, Vasilevko V, Grigoryan MM帕格尼尼-希尔A, Kim R, Cribbs DH, Fisher MJ. Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages. J神经炎症. 2017年6月5日;14(1):114. PubMed PMID: 28583195; PubMed Central PMCID: PMC5460510.
Chang R, Knox J, Chang J, Derbedrossian A, Vasilevko V, Cribbs D, Boado RJ, Pardridge WM, Sumbria RK. Blood-Brain Barrier Penetrating Biologic TNF-a Inhibitor for Alzheimer's Disease. Mol Pharm. 2017年7月3日;14(7):2340-2349. PubMed PMID: 28514851.

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